(히스테리 톤 H3)-리신36-데메치라제

본래의 표기는 「[히스테리 톤 H3]-리신36-데메치라제」입니다.이 기사에 붙일 수 있었던 제목은 기사명의 제약으로부터 부정확한 것이 되고 있습니다.

[히스테리 톤 H3]-리신36-데메치라제
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EC번호	1.14.11.27
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[히스테리 톤 H3]-리신36-데메치라제([histone-H3]-lysine-36 demethylase)는, 다음 화학반응을 촉매 하는 산화 환원 효소이다.

(1) 단백질-N⁶, N⁶-디메틸-L-리신+ 2-옥소 한패 탈산+ O₂ ${\displaystyle \rightleftharpoons }$ 단백질-N⁶-메틸-L-리신+호박산+포름알데히드+ CO₂

(2) 단백질-N⁶-메틸-L-리신+ 2-옥소 한패 탈산+ O₂ ${\displaystyle \rightleftharpoons }$ 단백질-L-리신+호박산+포름알데히드+ CO₂

효소의 조직명은 protein-N⁶, N⁶-dimethyl-L-lysine, 2-oxoglutarate:oxygen oxidoreductase로, 별명에 JHDM1A, JmjC domain-containing histone demethylase 1 A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N, 6-N-dimethyl-L-lysine, 2-oxoglutarate:oxygen oxidoreductase가 있다.

참고 문헌

• Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M.E., Borchers, C.H., Tempst, P. and Zhang, Y. (2006). "Histone demethylation by a family of JmjC domain-containing proteins.". Nature 439: 811-816. PMID 16362057. 

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