뿌레우 롬 쨍

뿌레우 롬 쨍 (pleuromutilin) ​​및 그 유도체는 곰팡이가 생산하는 항생제이다. 의 () 서브 유닛의 () 부분에 결합하여의 합성을 억제한다.

뿌레우 롬 쨍

(4 R 5 S 6 S 8 R, 9a R 10 R ) -6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro- 3a 9-propanocyclopenta [8] annulen-8-yl hydroxyacetate

식별 정보 | | | | | | |

• C [C @@ H] 1CC [C @@] 23CCC (= O) C @ H] 2 ​​[C @@] 1 (C @@ (H C [C @@] (C @ H ([C @@ H] 3C) O) (C) C = C) OC (= O) CO) C

• InChI = 1S / C22H34O5 / c1-6-20 (4) 11-16 (27-17 (25) 12-23) 21 (5) 13 (2) 7-9-22 (14 (3) 19 (20 ) 26) 10-8-15 (24) 18 (21) 22 / h6,13-14,16,18-19,23,26H, 1,7-12H2,2-5H3 / t13- 14 + 16 - 18 + 19 + 20- 21 + 22 + / m1 / s1 Key : ZRZNJUXESFHSIO-BKUNHTPHSA-N

InChI = 1 / C22H34O5 / c1-6-20 (4) 11-16 (27-17 (25) 12-23) 21 (5) 13 (2) 7-9-22 (14 (3) 19 (20) 26) 10-8-15 (24) 18 (21) 22 / h6,13-14,16,18-19,23,26H, 1,7-12H2,2-5H3 / t13- 14 + 16 18 + 19 + 20- 21 + 22 + / m1 / s1 Key : ZRZNJUXESFHSIO-BKUNHTPHBC

특성 | C22H34O5 | 378.5 g mol-1 특기없는 경우 데이터는 (25 ° C) (100 kPa)의 것이다.

이 항생제의 클래스는 의약품으로 승인 된 () (인간의), (), (동물의 사용) 및 임상 시험중인 약이다 () () (BC-3781)가있다.

역사

뿌레우 롬 쨍 항생제로 1951 년에 처음 발견 된 1960 년대되었다. 뿌레우 롬 쨍는 () (Clitopilus)의 Clitopilus passeckerianus (이전의 학명은 Pleurotus passeckerianus)으로부터 격리, Drosophila subatrata, Clitopilus scyphoides 다른 그늘 우라 베니 대나무 속의 종에서도 발견되고있다.

전체 합성

뿌레우 롬 쨍는 지금까지 여러보고되고있다.

각주

1. *Long, Katherine S; Lykke H. Hansen; Lene Jakobsen; Birte Vester (2006). Antimicrobial Agents and Chemotherapy*50(4) : 1458-1462. :.. 2. *Lolk, L .; Pøhlsgaard, J .; Jepsen, AS; Hansen, LH; Nielsen, H .; Steffansen, SI; Sparving, L .; Nielsen, AB et al. (2008). "A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome "__*51(16) : 4957-4967. :. 3. *Kavanagh, F .; Hervey, A .; Robbins, W. J. (1951). Proc. Natl. Acad. Sci. U. S. A.*37: 570-574.. 4. *Kavanagh, F .; Hervey, A .; Robbins, W. J. (1952). Proc. Natl. Acad. Sci. U. S. A.*38: 555-560.. 5. *Novak, R; Shlaes DM (2010). "The pleuromutilin antibiotics : a new class for human use"Current Opinion in Investigational Drugs*11(2) : 182-91. 6. *Birch, A. J .; Cameron, D. W .; Holzapfel C. W .; Rickards, R. W .. "The diterpenoid nature of pleuromutilin"_Chem. Ind. (London, U. K) _ : 374. 7. *Birch, AJ; Holzapfel CW; Rickards, RW (1966). "The structure and some aspects of the biosynthesis of pleuromutilin" [Tetrahedron (잡지) |] 22( S8) : 359-387. :. 8. *Arigoni, D. (1968). "Some studies in the biosynthesis of terpenes and related compounds"Pure Appl. Chem.*17: 331-348. :. 9. *Kilaru, Sreedhar; Catherine M. Collins; Amanda J. Hartley; Andy M. Bailey; Gary D. Foster (2009-09-18). Appl Environ Microbiol (American Society for Microbiology)*75(22) : 7196-7204. :.. 10. *Gibbons, E. G. (1982). "Total synthesis of (±) -pleuromutilin"__*104(6) :. 11. *Boeckman, Jr. RK; Springer, DM; Alessi, TR (1989). "Synthetic studies directed toward naturally occurring cyclooctanoids 2. A stereocontrolled assembly of (±) -pleuromutilin via a remarkable sterically demanding oxy- Cope rearrangement "__*111(21) : 8284-8286. :. 12. *Fazakerley, NJ; Helm, MD; Procter, DJ (2013). "Total Synthesis of (+) - Pleuromutilin"Chem. Eur. J.*19: 6718-6723 : . 13. *Murphy, S. K .; Zeng, M .; Herzon, S. B. (2017). "A modular and enantioselective synthesis of the pleuromutilin antibiotics"__*356(6341) : 956-959. :.

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Post Date : 2018-02-18 02:30

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