리트코르산-6β-히드로키시라제
| 리트코르산-6β-히드로키시라제 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 식별자 | |||||||||
| EC번호 | 1.14.13.94 | ||||||||
| 데이터 베이스 | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB 구조 | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
리트코르산-6β-히드로키시라제(lithocholate 6β-hydroxylase)는, 다음 화학반응을 촉매 하는 산화 환원 효소이다.
- 리트코르산+ NADPH + H+ + O2 6β-히드로키시리트코르산+ NADP+ + H2O
이 효소의 기질은 리트코르산, NADPH, H+와 O2로, 생성물은 6β-히드로키시리트코르산, NADP+와 H2O이다.
조직명은 lithocholate, NADPH:oxygen oxidoreductase (6β-hydroxylating)로, 별명에 lithocholate 6β-monooxygenase, CYP3A10, 6β-hydroxylase, cytochrome P450 3 A10/lithocholic acid 6β-hydroxylase가 있다.
참고 문헌
- Teixeira J, Gil G (1991). "Cloning, expression, and regulation of lithocholic acid 6β-hydroxylase". J. Biol. Chem. 266 (31): 21030□6. PMID 1840595.
- Chang TK, Teixeira J, Gil G, Waxman DJ (Pt 2). "The lithocholic acid 6β-hydroxylase cytochrome P-450, CYP 3 A10, is an active catalyst of steroid-hormone 6β-hydroxylation". Biochem. J. 291: 429□33. PMC 1132543. PMID 8484723.
- Subramanian A, Wang J, Gil G (1998). "STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3 A10/lithocholic acid 6β-hydroxylase". Nucleic. Acids. Res. 26 (9): 2173–8. doi:10.1093/nar/26. 9.2173. PMC 147524. PMID 9547277.
- Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem. 72.121801. 161712. PMID 12543708.
This article is taken from the Japanese Wikipedia 리트코르산-6β-히드로키시라제
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