2,4-지아미노펜탄산데히드로게나제

2,4-지아미노펜탄산데히드로게나제
식별자
EC번호	1.4.1.12
CAS 등록 번호	39346-26-4
데이터 베이스
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB 구조	RCSB PDB PDBe PDBj PDBsum
유전자 온트로지	AmiGO / EGO
검색 PMC articles PubMed articles NCBI proteins

2,4-지아미노펜탄산데히드로게나제(2,4-diaminopentanoate dehydrogenase)는, 리신 분해, 아르기닌・프로 인 대사 효소의 하나로, 다음 화학반응을 촉매 하는 산화 환원 효소이다.

2,4-지아미노펜탄산+ H₂O + NAD(P)+ ${\displaystyle \rightleftharpoons }$ 2-아미노-4-옥소 펜 탄산+ NH₃ + NAD(P) H + H⁺

반응식대로, 이 효소의 기질은2,4-지아미노펜탄산과 H₂O와 NAD⁺ (NADP⁺), 생성물은2-아미노-4-옥소 펜 탄산과 NH₃와 NADH (NADPH)와 H⁺이다.

조직명은 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)로, 별명에 2,4-diaminopentanoic acid C₄ dehydrogenase가 있다.

참고 문헌

• Somack R, Costilow RN (1973). "2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein". J. Biol. Chem. 248: 385□8. PMID 4684685. 
• Stadtman TC (1973). "Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase)". Adv. Enzymol. Relat. Areas Mol. Biol. 38: 441□445. 
• Tsuda Y, Friedmann HC (1970). "Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide". J. Biol. Chem. 245: 5914□26. PMID 4394942. 

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